| University of California at Los Angeles | Million Dollar Hoods-Archiving the Age of Mass Incarceration | 12/11/20 | $3,650,000 | Los Angeles, CA, United States | Other |
| New England Foundation for the Arts, Inc. | National Theater Program | 03/13/14 | $3,625,000 | Boston, MA, United States | Arts and Culture |
| American Council of Learned Societies | Mellon Leading Edge Fellowships | 09/18/20 | $3,600,000 | New York, NY, United States | Higher Learning |
| Institute for Citizens and Scholars | Mellon Fellowships Program | 06/21/02 | $3,600,000 | Princeton, NJ, United States | Higher Learning |
| Arizona State University | RaceB4Race: Sustaining, Building, Innovating | 09/13/21 | $3,500,000 | Tempe, AZ, United States | Higher Learning |
| City of Bisbee | Camp Naco | 12/08/22 | $3,500,000 | Bisbee, AZ, United States | Other |
| American Council of Learned Societies | Public Fellows Program | 09/12/19 | $3,500,000 | New York, NY, United States | Higher Learning |
| New York City Center, Inc. | Fall for Dance Festival Endowment | 12/15/06 | $3,500,000 | New York, NY, United States | Arts and Culture |
| Merit School of Music | Chicago Musical Pathways Initiative | 09/06/18 | $3,500,000 | Chicago, IL, United States | Arts and Culture |
| Rutgers, The State University of New Jersey | Humanities Fellowship Initiatives - Phase III | 03/13/14 | $3,500,000 | New Brunswick, NJ, United States | Higher Learning |
| Northwestern University | Northwestern University/Art Institute of Chicago Center for Scientific Studies in the Arts (NU-ACCESS) Phase 2 | 05/31/18 | $3,500,000 | Evanston, United States | Arts and Culture |
| Seattle Art Museum | Asian Paintings Conservation Center | 09/11/17 | $3,500,000 | Seattle, WA, United States | Arts and Culture |
| The Rebuild Foundation NFP | St. Laurence School Arts and Industry and Stony Island Arts Bank | 09/13/21 | $3,500,000 | Chicago, IL, United States | Humanities in Place |
| National Gallery of Art | Gallery's Building Program | 12/14/77 | $3,500,000 | Washington, DC, United States | Arts and Culture |
| Southern Education Foundation, Inc. | Black College Libraries | 12/14/89 | $3,500,000 | Atlanta, GA, United States | Higher Learning |
| University of Southern California | Irei Names | 03/11/22 | $3,500,000 | Los Angeles, CA, United States | Other |
| American Council of Learned Societies | Dissertation Completion Fellowships | 03/05/20 | $3,500,000 | New York, NY, United States | Higher Learning |
| Rutgers, The State University of New Jersey | Humanities Fellowship Initiatives - Phase II | 06/03/11 | $3,500,000 | New Brunswick, NJ, United States | Higher Learning |
| Thomas Jefferson Foundation, Inc. | Next Generation Getting Word: An Archive of Black Freedom | 12/08/22 | $3,500,000 | Charlottesville, VA, United States | Other |
| The Studio Museum in Harlem | Critical Collections | 06/08/22 | $3,500,000 | New York, NY, United States | Arts and Culture |
| Institute for Citizens and Scholars | Mellon Fellowships | 03/19/87 | $3,500,000 | Princeton, NJ, United States | Higher Learning |
| Associated Colleges of the South, Inc. | Environmental Studies | 09/18/08 | $3,500,000 | Atlanta, GA, United States | Higher Learning |
| Anthology of Recorded Music, Inc. | General Operations | 03/20/06 | $3,500,000 | Brooklyn, NY, United States | Public Knowledge |
| Rockefeller University | Life Sciences Education | 03/30/90 | $3,500,000 | New York, NY, United States | Higher Learning |
| Ekvnv Yefolecvlke | Vlahoke | 12/10/21 | $3,500,000 | Weogufka, AL, United States | Humanities in Place |
