| National Gallery of Art | Gallery's Building Program | 12/18/75 | $7,500,000 | Washington, DC, United States | Arts and Culture |
| National Gallery of Art | Endowment | 03/22/91 | $7,500,000 | Washington, DC, United States | Arts and Culture |
| Centro de Economía Creativa, Inc. | Puerto Rico Arts Ecosystem | 12/13/21 | $8,000,000 | San Juan, PR, United States | Other |
| ARTstor, Inc. | General Support | 10/01/04 | $8,000,000 | New York, NY, United States | Public Knowledge |
| American Council of Learned Societies | Mellon Centennial Fund | 12/08/16 | $8,000,000 | New York, NY, United States | Higher Learning |
| Associated Colleges of the Midwest, Inc. | Undergraduate and Faculty Fellows Program for a Diverse Professoriate | 03/12/15 | $8,100,000 | Chicago, IL, United States | Higher Learning |
| American Council of Learned Societies | New Tenured Faculty Fellowships (Burkhardt Fellowships) | 03/10/16 | $8,220,000 | New York, NY, United States | Higher Learning |
| American Council of Learned Societies | MMUF Administration and Annual Institutional Renewals | 06/30/22 | $8,500,000 | New York, NY, United States | Higher Learning |
| ARTstor, Inc. | Collection Development Fund V | 12/15/06 | $8,550,000 | New York, NY, United States | Public Knowledge |
| American Council of Learned Societies | Dissertation Completion Fellowships | 12/10/15 | $8,850,000 | New York, NY, United States | Higher Learning |
| California Community Foundation | Los Angeles Emergency Response | 12/07/20 | $10,000,000 | Los Angeles, CA, United States | Arts and Culture |
| Detroit Institute of Arts | Perpetual Ownership of Assets | 03/13/14 | $10,000,000 | Detroit, MI, United States | Arts and Culture |
| University of California at Irvine | UCHRI Endowment | 12/07/17 | $10,000,000 | Irvine, CA, United States | Higher Learning |
| National Gallery of Art | Gallery's Building Program | 06/18/74 | $10,000,000 | Washington, DC, United States | Arts and Culture |
| The Studio Museum in Harlem | Capital Campaign | 12/08/22 | $10,000,000 | New York, NY, United States | Other |
| New York Community Trust | NYC COVID-19 Response & Impact Fund | 03/27/20 | $10,000,000 | New York, NY, United States | Other |
| University of Wisconsin at Madison | Strengthening the Core Humanities | 12/09/10 | $10,000,000 | Madison, WI, United States | Higher Learning |
| Smithsonian Institution | Smithsonian Institution - NMAAHC Endowment | 12/10/15 | $10,000,000 | Washington, DC, United States | Arts and Culture |
| American Council of Learned Societies | Early Career Fellowships | 06/19/09 | $10,623,000 | New York, NY, United States | Higher Learning |
| City of Richmond | Shockoe Heritage Campus Center: Transforming Richmond's Core Commemorative Landscape | 12/08/22 | $11,000,000 | Richmond, VA, United States | Other |
| Council on Library and Information Resources | Digitizing Hidden Special Collections | 12/07/17 | $13,248,000 | Washington, DC, United States | Public Knowledge |
| National Park Foundation | Expanding the Boundaries of America250 | 03/11/22 | $13,431,000 | Washington, DC, United States | Higher Learning |
| Rutgers, The State University of New Jersey | The Institute for the Study of Global Racial Justice (ISGRJ) | 09/18/20 | $15,000,000 | New Brunswick, NJ, United States | Higher Learning |
| Library of Congress | Of the People: Widening the Path | 12/11/20 | $15,000,000 | Washington, DC, United States | Public Knowledge |
| The Regents of the University of California | President's Postdoctoral Fellowship Program HSI Humanities Initiative | 06/11/21 | $15,000,000 | Oakland, CA, United States | Higher Learning |
