| National Humanities Center | Fellowships Endowment | 09/18/08 | $3,000,000 | Research Triangle Park, NC, United States | Higher Learning |
| Association of Performing Arts Professionals | Restarting the Arts | 07/28/21 | $3,000,000 | Washington, DC, United States | Arts and Culture |
| University of Chicago | Scholarly Careers Initiative | 09/06/18 | $3,000,000 | Chicago, IL, United States | Higher Learning |
| John F. Kennedy Center for the Performing Arts | Social Impact Fund | 09/18/20 | $3,000,000 | Washington, DC, United States | Arts and Culture |
| American Council of Learned Societies | ACLS Digital Extension Grants | 09/06/18 | $3,000,000 | New York, NY, United States | Public Knowledge |
| American Council of Learned Societies | Electronic Publishing Initiative for Scholarly Monographs in History | 06/18/99 | $3,000,000 | New York, NY, United States | Public Knowledge |
| American Academy of Arts and Sciences | Humanities Indicators Endowment | 12/06/12 | $3,000,000 | Cambridge, MA, United States | Higher Learning |
| Massachusetts Institute of Technology | Open CourseWare - Phase II | 12/15/03 | $3,000,000 | Cambridge, MA, United States | Higher Learning |
| Trinity College | Centers of Excellence | 12/15/06 | $3,000,000 | Hartford, CT, United States | Higher Learning |
| Rockefeller University | Molecular Biology | 10/06/82 | $3,000,000 | New York, NY, United States | Past Programs |
| Population Council | Capital Base Endowment | 12/12/94 | $3,000,000 | New York, NY, United States | Past Programs |
| Northwestern University | Chinese Cave Art | 12/17/99 | $3,000,000 | Evanston, IL, United States | Public Knowledge |
| Salem State University | The Digital Ethnic Futures Consortium (DEFCon) | 09/13/21 | $3,000,000 | Salem, MA, United States | Higher Learning |
| Johns Hopkins University | Enhanced Support for the Mellon Endowment for Graduate Studies in the Humanities | 06/03/11 | $3,000,000 | Baltimore, MD, United States | Higher Learning |
| Virginia Polytechnic Institute and State University | Monuments across Appalachian Virginia | 12/08/22 | $3,000,000 | Blacksburg, VA, United States | Other |
| National Gallery of Art | Patrons Permanent Fund | 03/28/85 | $3,000,000 | Washington, DC, United States | Arts and Culture |
| Institute for Citizens and Scholars | Mellon Fellowships Program | 06/16/00 | $3,000,000 | Princeton, NJ, United States | Higher Learning |
| University of Michigan | Our Compelling Interests (OCI) at the Center for Social Solutions | 03/15/18 | $3,000,000 | Ann Arbor, MI, United States | Higher Learning |
| Social Science Research Council | Postdoctoral Fellowships for Transregional Research - Asian Area Studies | 03/12/15 | $3,000,000 | Brooklyn, NY, United States | Higher Learning |
| Population Council | General support | 06/06/85 | $3,000,000 | New York, NY, United States | Past Programs |
| Brown University | Graduate Student Support - Endowment | 09/18/08 | $3,000,000 | Providence, RI, United States | Higher Learning |
| American Council of Learned Societies | New Faculty Fellowships | 09/15/11 | $3,000,000 | New York, NY, United States | Higher Learning |
| VolkswagenStiftung | Fellowship Exchange Program | 09/15/11 | $3,000,000 | Hanover, Germany | Higher Learning |
| Jazz at Lincoln Center, Inc. | Artistic Initiatives and Operating Reserve | 12/01/11 | $3,000,000 | New York, NY, United States | Arts and Culture |
| United Negro College Fund, Inc. | Mellon Mays Undergraduate Fellowship Program - 2009 Renewal | 12/10/09 | $3,032,000 | Washington, DC, United States | Higher Learning |
