| Institute for Citizens and Scholars | Career Enhancement | 06/16/06 | $2,700,000 | Princeton, NJ, United States | Higher Learning |
| Society of Architectural Historians | Architecture Visual Resource Network | 03/14/08 | $2,718,000 | Chicago, IL, United States | Public Knowledge |
| Council on Library and Information Resources | Recordings at Risk: Audiovisual Preservation | 09/15/16 | $2,725,000 | Washington, DC, United States | Public Knowledge |
| New York University | Graduate Student Support in the Humanities | 12/04/14 | $2,725,000 | New York, NY, United States | Higher Learning |
| University of California at Irvine | Graduate Education Reform | 06/04/15 | $2,730,000 | Irvine, CA, United States | Higher Learning |
| Institute for Citizens and Scholars | Mellon Fellowships Program | 06/09/97 | $2,750,000 | Princeton, NJ, United States | Higher Learning |
| Northwestern University | Intercultural American Studies Council | 09/06/18 | $2,750,000 | Evanston, IL, United States | Higher Learning |
| Population Council | General Support | 06/16/82 | $2,750,000 | New York, NY, United States | Past Programs |
| American Council of Learned Societies | Dissertation Innovation Fellowships | 03/11/22 | $2,750,000 | New York, NY, United States | Higher Learning |
| American Council of Learned Societies | New Tenured Faculty Fellowships (Burkhardt Fellowships) | 03/06/19 | $2,750,000 | New York, NY, United States | Higher Learning |
| Institute for Citizens and Scholars | Mellon Fellowships Program | 06/17/96 | $2,750,000 | Princeton, NJ, United States | Higher Learning |
| Council on Library and Information Resources | Postdoctoral Fellowships in Support of Data Curation for African American and African Studies | 09/06/18 | $2,750,000 | Washington, DC, United States | Public Knowledge |
| Great Lakes Colleges Association, Inc. | Expanding Collaboration Initiative | 09/13/12 | $2,750,000 | Ann Arbor, MI, United States | Higher Learning |
| The Art Institute of Chicago | Conservation Science Endowment | 12/15/00 | $2,750,000 | Chicago, IL, United States | Arts and Culture |
| University of Michigan | Transfer Bridges to the Humanities - Phase II | 12/10/21 | $2,756,000 | Ann Arbor, MI, United States | Higher Learning |
| Institute for Citizens and Scholars | Mellon Fellowships | 03/27/86 | $2,780,000 | Princeton, NJ, United States | Higher Learning |
| Institute of International Education, Inc. | Artist Protection Fund | 03/12/15 | $2,785,000 | New York, NY, United States | Arts and Culture |
| Rutgers, The State University of New Jersey | Humanities Fellowship Initiatives - Phase I | 06/13/08 | $2,793,000 | New Brunswick, NJ, United States | Higher Learning |
| American Council of Learned Societies | Collaborative Research Fellowships | 06/05/14 | $2,800,000 | New York, NY, United States | Higher Learning |
| JSTOR | Art History Cluster | 12/15/00 | $2,800,000 | New York, NY, United States | Public Knowledge |
| Southern Education Foundation, Inc. | Katrina - New Orleans Response | 09/17/05 | $2,800,000 | Atlanta, GA, United States | Other |
| University of Wisconsin at Madison | CHCI Global Humanities Institutes | 12/09/19 | $2,800,000 | Madison, WI, United States | Higher Learning |
| Council on Library and Information Resources | Recordings at Risk: Audiovisual Preservation | 03/06/19 | $2,807,000 | Arlington, VA, United States | Public Knowledge |
| New York University | New York Historical Society Library Collections | 06/09/97 | $2,850,000 | New York, NY, United States | Higher Learning |
| Social Science Research Council | Mellon Mays Undergraduate Fellowship Program - Graduate Initiatives Program | 09/15/11 | $2,875,000 | Brooklyn, NY, United States | Higher Learning |
