| Goucher College | Hewlett-Mellon Program | 10/08/80 | $75,000 | Baltimore, MD, United States | Higher Learning |
| Harvard University | Clinical Epidemiology | 10/08/80 | $750,000 | Cambridge, MA, United States | Past Programs |
| Hope College | Hewlett-Mellon Program | 10/08/80 | $75,000 | Holland, MI, United States | Higher Learning |
| Stillman College | Black Colleges Program | 10/08/80 | $100,000 | Tuscaloosa, AL, United States | Higher Learning |
| Knox College | Hewlett-Mellon Program | 10/08/80 | $75,000 | Galesburg, IL, United States | Higher Learning |
| Mariners Museum | Maritime Museum Program | 10/08/80 | $150,000 | Newport News, VA, United States | Arts and Culture |
| Museum of Modern Art | Research Libraries Information Network | 10/08/80 | $21,000 | New York, NY, United States | Higher Learning |
| National Academy of Sciences | Institute of Medicine - Health Sciences Policy | 10/08/80 | $35,000 | Washington, DC, United States | Past Programs |
| Old Dartmouth Historical Society | Maritime Museum Program | 10/08/80 | $60,000 | New Bedford, MA, United States | Arts and Culture |
| Williams College | Hewlett-Mellon Program | 10/08/80 | $125,000 | Williamstown, MA, United States | Higher Learning |
| American Association for the Advancement of the Humanities | Effort to increase membership | 10/08/80 | $35,000 | Washington, DC, United States | Higher Learning |
| Association of American University Presses, Inc. | Specialized Scholary Publishing | 10/08/80 | $100,000 | New York, NY, United States | Higher Learning |
| Conservation Foundation | Capital Fund | 10/08/80 | $500,000 | Washington, DC, United States | Past Programs |
| Corporation for Public Broadcasting | International Activities Program | 10/08/80 | $150,000 | Washington, DC, United States | Arts and Culture |
| Environmental Law Institute | General support | 10/08/80 | $300,000 | Washington, DC, United States | Past Programs |
| Planned Parenthood of New York City, Inc. | General Support | 10/08/80 | $250,000 | New York, NY, United States | Past Programs |
| Recording for the Blind, Inc. | Catalogue Conversion | 10/08/80 | $150,000 | Princeton, NJ, United States | Higher Learning |
| Stanford University | 1980s Fund | 10/08/80 | $1,250,000 | Stanford, CA, United States | Higher Learning |
| University of Chicago | 1980s Fund | 10/08/80 | $1,350,000 | Chicago, IL, United States | Higher Learning |
| University of Pennsylvania | Clinical Epidemiology | 10/08/80 | $525,000 | Philadelphia, PA, United States | Past Programs |
| Pierpont Morgan Library | Research Libraries Information Network | 10/08/80 | $35,000 | New York, NY, United States | Higher Learning |
| New York University | NYU/Columbia Press Project | 10/08/80 | $35,000 | New York, NY, United States | Higher Learning |
| Maine Maritime Museum | Maritime Museum Program | 10/08/80 | $75,000 | Bath, ME, United States | Arts and Culture |
| Yale University | James Boswell Papers | 10/08/80 | $65,000 | New Haven, CT, United States | Higher Learning |
| American Academy in Rome | Fellowship Program/Financial Analysis | 10/08/80 | $275,000 | New York, NY, United States | Higher Learning |
