| University of Rochester | Medical Schools Program | 06/14/88 | $225,000 | Rochester, NY, United States | Past Programs |
| Knickerbocker Hospital | Medicine and Population | 12/16/69 | $4,000 | New York, NY, United States | Past Programs |
| Mayo Clinic | Molecular Medicine | 06/15/83 | $480,000 | Rochester, MN, United States | Past Programs |
| University of California at San Diego | Reproductive Medicine | 12/12/79 | $600,000 | La Jolla, CA, United States | Past Programs |
| University of California at San Diego | Reproductive Medicine | 06/19/84 | $600,000 | La Jolla, CA, United States | Past Programs |
| University of California at San Diego | Reproductive Medicine | 12/15/88 | $600,000 | La Jolla, CA, United States | Past Programs |
| King’s College London | Prototype Prosopography of Medieval Physicians | 03/19/10 | $50,000 | London, United Kingdom | Public Knowledge |
| Utah State University | Scientific Networking Meeting | 01/23/06 | $8,600 | Logan, UT, United States | Past Programs |
| New York Academy of Sciences | Science Policy Meetings | 06/14/88 | $5,000 | New York, NY, United States | Other |
| Australian National University | Urbanization/Megacities Project | 06/21/02 | $150,000 | Acton, ACT, Australia | Past Programs |
| Lehigh University | Mellon Professorship | 12/14/72 | $744,600 | Bethlehem, PA, United States | Higher Learning |
| The Library Company of Philadelphia | Mellon Scholars Program | 09/15/16 | $500,000 | Philadelphia, PA, United States | Higher Learning |
| Vassar College | Mellon Professorship | 09/15/70 | $750,000 | Poughkeepsie, NY, United States | Higher Learning |
| University of Oxford | Mellon Professorship | 06/19/84 | $1,000,000 | Oxford, United Kingdom | Higher Learning |
| The Library Company of Philadelphia | Mellon Scholars Program | 09/18/20 | $500,000 | Philadelphia, PA, United States | Higher Learning |
| The Library Company of Philadelphia | Mellon Scholars Program | 03/14/13 | $425,000 | Philadelphia, PA, United States | Higher Learning |
| University of Houston | Mellon Research Scholars Program | 06/01/17 | $500,000 | Houston, TX, United States | Higher Learning |
| University of Southern California | Mellon Professorship | 09/27/74 | $750,000 | Los Angeles, CA, United States | Higher Learning |
| Yale University | Paul Mellon Professorship | 10/02/85 | $1,750,000 | New Haven, CT, United States | Higher Learning |
| Brooklyn College | Mellon Transfer Student Research Program | 12/11/20 | $1,000,000 | Brooklyn, NY, United States | Higher Learning |
| Williams College | Mellon Professorship | 12/14/72 | $750,000 | Williamstown, MA, United States | Higher Learning |
| American Music Center, Inc. | Online Services and a Restructuring of Member Programs | 06/15/07 | $300,000 | New York, NY, United States | Arts and Culture |
| GuideStar USA, Inc. | Membership Program | 08/19/13 | $25,000 | Williamsburg, VA, United States | Other |
| GuideStar USA, Inc. | Membership Program | 07/21/14 | $25,000 | Williamsburg, VA, United States | Other |
| American Academy of Arts and Sciences | Membership Policy | 03/22/91 | $50,000 | Cambridge, MA, United States | Higher Learning |
