| Yale University | Centers for the Study of Race and Ethnicity: Research, Teaching, and Partnerships | 12/09/19 | $4,000,000 | New Haven, CT, United States | Higher Learning |
| ARTstor, Inc. | Collection Development Fund III | 12/17/04 | $4,000,000 | New York, NY, United States | Public Knowledge |
| National Humanities Center | Fellowship Endowment | 03/22/91 | $4,000,000 | Research Triangle Park, NC, United States | Higher Learning |
| Vassar College | Anne Tatlock Endowments for Faculty Support | 03/15/12 | $4,000,000 | Poughkeepsie, NY, United States | Higher Learning |
| Middlebury College | Centers Strategy [National Institute for Technology & Liberal Education] | 09/21/01 | $4,000,000 | Middlebury, VT, United States | Higher Learning |
| American Indian College Fund | TCU Student Emergency Support | 04/20/20 | $4,000,000 | Denver, CO, United States | Higher Learning |
| Dance Theatre of Harlem, Inc. | Artistic Initiatives and Capacity Building | 12/09/19 | $4,000,000 | New York, NY, United States | Arts and Culture |
| Woodrow Wilson National Fellowship Foundation | Career Enhancement and Dissertation Support Program | 05/31/18 | $3,993,000 | Princeton, United States | Higher Learning |
| Great Lakes Colleges Association, Inc. | Faculty Development and Renewal | 12/17/08 | $3,980,000 | Ann Arbor, MI, United States | Higher Learning |
| The Brooklyn Institute of Arts and Sciences | Costume Collection | 03/18/05 | $3,925,000 | Brooklyn, NY, United States | Arts and Culture |
| New England Foundation for the Arts, Inc. | National Dance Project | 12/07/17 | $3,900,000 | Boston, MA, United States | Arts and Culture |
| Appalachian College Association | Appalachian College Program - Technology | 12/14/98 | $3,900,000 | Berea, KY, United States | Higher Learning |
| American Council of Learned Societies | Collaborative Fellowships | 06/13/08 | $3,875,000 | New York, NY, United States | Higher Learning |
| Carnegie Mellon University | Art Conservation - Research Center | 12/11/07 | $3,870,000 | Pittsburgh, PA, United States | Arts and Culture |
| Woodrow Wilson National Fellowship Foundation | Junior Faculty Career Enhancement Fellowship and Dissertation Support Program | 03/12/15 | $3,800,000 | Princeton, NJ, United States | Higher Learning |
| New England Foundation for the Arts, Inc. | National Theater Project | 03/09/17 | $3,770,000 | Boston, MA, United States | Arts and Culture |
| New York Foundation for the Arts, Inc. | New York Theater Program - Renewal | 03/14/13 | $3,750,000 | Brooklyn, NY, United States | Arts and Culture |
| American Council of Learned Societies | New Tenured Faculty Fellowships - Burkhardt Fellowships | 03/19/04 | $3,701,000 | New York, NY, United States | Higher Learning |
| Social Science Research Council | Dissertation Proposal Development Fellowships | 03/10/11 | $3,700,000 | Brooklyn, NY, United States | Higher Learning |
| Ithaka Harbors, Inc. | Capital Fund IV | 09/17/05 | $3,700,000 | New York, NY, United States | Public Knowledge |
| New England Foundation for the Arts, Inc. | National Theater Program | 03/13/14 | $3,625,000 | Boston, MA, United States | Arts and Culture |
| Woodrow Wilson National Fellowship Foundation | Mellon Fellowships Program | 06/21/02 | $3,600,000 | Princeton, NJ, United States | Higher Learning |
| American Council of Learned Societies | Mellon Leading Edge Fellowships | 09/18/20 | $3,600,000 | New York, NY, United States | Higher Learning |
| Merit School of Music | Chicago Musical Pathways Initiative | 09/06/18 | $3,500,000 | Chicago, IL, United States | Arts and Culture |
| American Council of Learned Societies | Public Fellows Program | 09/12/19 | $3,500,000 | New York, NY, United States | Higher Learning |
