| University of California at Santa Cruz | Graduate Student Success Initiatives | 06/01/17 | $1,500,000 | Santa Cruz, CA, United States | Higher Learning |
| Center for Curatorial Leadership | Curatorial Leadership Training | 06/01/17 | $1,500,000 | New York, NY, United States | Arts and Culture |
| Juilliard School | Strengthen Institution | 06/20/72 | $1,500,000 | New York, NY, United States | Arts and Culture |
| New York City Ballet, Inc. | Touring Endowment | 06/17/96 | $1,500,000 | New York, NY, United States | Arts and Culture |
| University of Chicago | Print on Demand | 09/21/01 | $1,500,000 | Chicago, IL, United States | Public Knowledge |
| Open Source Applications Foundation | Westwood Development Project | 09/19/03 | $1,500,000 | San Francisco, CA, United States | Higher Learning |
| University of Chicago | Mellon Instructors Program | 10/07/87 | $1,500,000 | Chicago, IL, United States | Higher Learning |
| The British Library | Preservation Microfilming | 09/29/88 | $1,500,000 | London, United Kingdom | Public Knowledge |
| Columbia University | 1980s Fund | 10/08/80 | $1,500,000 | New York, NY, United States | Higher Learning |
| Amherst College | Transforming Residential Liberal Education for a New Population of Students | 12/10/15 | $1,500,000 | Amherst, MA, United States | Higher Learning |
| Virginia Museum of Fine Arts Foundation | African Art Collection | 12/10/15 | $1,500,000 | Richmond, VA, United States | Arts and Culture |
| Emory University | Humanities PhD Interventions | 12/08/16 | $1,500,000 | Atlanta, GA, United States | Higher Learning |
| Ithaka Harbors, Inc. | Portico - E-Archive | 12/12/05 | $1,500,000 | New York, NY, United States | Public Knowledge |
| Haverford College | Postdoctoral Fellowships - Endowment | 12/12/05 | $1,500,000 | Haverford, PA, United States | Higher Learning |
| Emeriti Consortium for Retirement Health Solutions | Administrative Funding | 12/15/06 | $1,500,000 | New Windsor, NY, United States | Higher Learning |
| College of William & Mary | Environmental Studies | 12/11/07 | $1,500,000 | Williamsburg, VA, United States | Higher Learning |
| Guttmacher Institute, Inc. | Core Institutional Support | 12/15/00 | $1,500,000 | New York, NY, United States | Past Programs |
| United Negro College Fund, Inc. | UNCF/Mellon Faculty Career Enhancement | 12/15/00 | $1,500,000 | Washington, DC, United States | Higher Learning |
| Population Council | International Committee for Contraceptive Research | 12/17/01 | $1,500,000 | New York, NY, United States | Past Programs |
| Metropolitan Museum of Art | Conservation Science Endowment | 12/16/02 | $1,500,000 | New York, NY, United States | Arts and Culture |
| Social Science Research Council | Mellon Mays Undergraduate Fellowship Program - Summer Conferences | 12/16/02 | $1,500,000 | Brooklyn, NY, United States | Higher Learning |
| JSTOR | Initital Phase | 12/18/95 | $1,500,000 | New York, NY, United States | Public Knowledge |
| Nature Conservancy, Inc. | Ecosystems Research | 12/18/95 | $1,500,000 | Arlington, VA, United States | Past Programs |
| National Gallery of Art | Conservation Program | 12/14/83 | $1,500,000 | Washington, DC, United States | Arts and Culture |
| Medical College of Hampton Roads | CONRAD - Consortium for Industrial Collaboration on Contraceptive Research | 03/15/02 | $1,500,000 | Arlington, VA, United States | Past Programs |
