| New York Public Library | Preservation of At-Risk Audiovisual Collections Phase Two | 12/07/17 | $2,975,000 | New York, NY, United States | Scholarly Communications |
| Arizona State University | Curation of the Library Print Collection | 12/07/17 | $381,000 | Tempe, AZ, United States | Scholarly Communications |
| University of Notre Dame | Campus Library and Museum Collaboration | 12/07/17 | $455,000 | Notre Dame, IN, United States | Scholarly Communications |
| University of Oregon | Campus Library and Museum Collaboration | 12/07/17 | $300,000 | Eugene, OR, United States | Scholarly Communications |
| Michigan State University | Enslaved: Peoples of the Historic Slave Trade | 12/07/17 | $1,472,000 | East Lansing, MI, United States | Scholarly Communications |
| American Council of Learned Societies | Mellon/ACLS Community College Faculty Research Fellowships | 12/07/17 | $4,200,000 | New York, NY, United States | Higher Education and Scholarship in the Humanities |
| Council of Independent Colleges | Humanities Research for the Public Good | 12/07/17 | $1,290,000 | Washington, DC, United States | Higher Education and Scholarship in the Humanities |
| WNET | Arts 24/7 | 12/07/17 | $1,000,000 | New York, NY, United States | Arts and Cultural Heritage |
| Studio Museum in Harlem, Inc. | Curatorial Fund Phase III | 12/07/17 | $1,000,000 | New York, NY, United States | Arts and Cultural Heritage |
| Randolph-Macon College | Enhancing Music Education | 12/07/17 | $250,000 | Ashland, VA, United States | Higher Education and Scholarship in the Humanities |
| Earshot Jazz Society of Seattle | Jazz Ecosystem | 12/07/17 | $400,000 | Seattle, WA, United States | Arts and Cultural Heritage |
| Gateways Music Festival, Inc. | Gateways Festival | 12/07/17 | $300,000 | Rochester, NY, United States | Arts and Cultural Heritage |
| Kalamazoo College | Ensuring That the K-Plan Enables and Encourages All Students to Engage in Experiential Learning | 12/07/17 | $800,000 | Kalamazoo, MI, United States | Higher Education and Scholarship in the Humanities |
| Massachusetts Institute of Technology | Digital Humanities | 12/07/17 | $1,300,000 | Cambridge, MA, United States | Higher Education and Scholarship in the Humanities |
| Howard University | Mellon Mays Undergraduate Fellowship | 12/07/17 | $480,000 | Washington, DC, United States | Higher Education and Scholarship in the Humanities |
| Morgan State University | African American Studies Minor Concentration | 12/07/17 | $375,000 | Baltimore, MD, United States | Higher Education and Scholarship in the Humanities |
| Civic Nation | Reach Higher Text Messaging Initiative | 12/07/17 | $1,430,000 | Washington, DC, United States | Higher Education and Scholarship in the Humanities |
| British Museum | ResearchSpace | 12/07/17 | $1,700,000 | London, United Kingdom | Arts and Cultural Heritage |
| University of California at Irvine | UCHRI Endowment | 12/07/17 | $10,000,000 | Irvine, CA, United States | Higher Education and Scholarship in the Humanities |
| Rhizome Communications, Inc. | Webrecorder, a web archiving tool: Phase Two | 12/07/17 | $1,000,000 | New York, NY, United States | Scholarly Communications |
| The Aspen Institute Inc. | Aspen Presidential Fellowship & Alumni Network | 12/07/17 | $1,800,000 | Washington, DC, United States | Higher Education and Scholarship in the Humanities |
| Texas A&M University | Planning for Digital Edition Publishing Cooperatives | 12/07/17 | $75,000 | College Station, TX, United States | Scholarly Communications |
| Massachusetts Historical Society | Planning for Digital Edition Publishing Cooperatives | 12/07/17 | $62,000 | Boston, MA, United States | Scholarly Communications |
| University of California at Santa Cruz | Digital Edition Publishing Cooperatives | 12/07/17 | $100,000 | Santa Cruz, CA, United States | Scholarly Communications |
| Alternate Roots, Inc. | Artistic Assistance, ROOTS Weekends, and Partners in Action Programs | 12/07/17 | $600,000 | Atlanta, GA, United States | Arts and Cultural Heritage |
