| University of Natal | Digital Imaging of South Africa | 12/15/03 | $1,150,000 | Durban, South Africa | International Higher Education and Strategic Projects |
| University of Fort Hare | Ecosystems Research and Training [Brand] | 12/15/03 | $34,000 | Alice, South Africa | Past Programs |
| Mangosuthu Technikon | ESAL Library Consortium | 12/17/04 | $417,000 | Durban, South Africa | International Higher Education and Strategic Projects |
| University of Cape Town | Writing Center Internships [MMUF] | 12/17/04 | $130,000 | Cape Town, South Africa | Higher Learning |
| South African National Biodiversity Institute | African Plants Initiative | 12/12/05 | $480,000 | Pretoria, South Africa | Past Programs |
| South African National Parks | Junior Scientists - Kruger | 12/12/05 | $208,000 | Pretoria, South Africa | Past Programs |
| University of the Witwatersrand | Mellon Mays Undergraduate Fellowship Program | 12/11/07 | $400,000 | Johannesburg, South Africa | Higher Learning |
| University of the Witwatersrand | Chair of Human Evolution | 12/11/07 | $1,300,000 | Johannesburg, South Africa | International Higher Education and Strategic Projects |
| University of the Witwatersrand | Research Bridges [Rogers] | 12/10/09 | $296,000 | Johannesburg, South Africa | Past Programs |
| Western Cape Tertiary Institutions Trust | Library Automation for the Cape Library Consortium | 09/20/96 | $1,500,000 | Cape Town, South Africa | Other |
| Rhodes University | Graduate Fellowships | 09/12/97 | $1,000,000 | Grahamstown, South Africa | Other |
| Eastern Cape Higher Education Association Trust | South East Academic Libraries System | 07/01/99 | $44,500 | Port Elizabeth, South Africa | International Higher Education and Strategic Projects |
| Institute for Democracy in South Africa | Truth and Reconciliation Commission | 10/06/00 | $30,000 | Pretoria, South Africa | International Higher Education and Strategic Projects |
| University of Natal | Heritage Information Network | 12/17/01 | $190,000 | Durban, South Africa | International Higher Education and Strategic Projects |
| University of the Witwatersrand | South African Rock Art Digital Archive | 10/11/02 | $20,500 | Johannesburg, South Africa | International Higher Education and Strategic Projects |
| Western Cape Tertiary Institutions Trust | Library Automation for the Cape Library Consortium | 12/14/98 | $277,000 | Cape Town, South Africa | International Higher Education and Strategic Projects |
| South African National Parks | Research Bridges | 05/31/12 | $227,000 | Pretoria, South Africa | Past Programs |
| University of the Free State | The New Student Movement in South Africa - From #RhodesMustFall to #FeesMustFall | 12/19/16 | $150,000 | Bloemfontein, South Africa | International Higher Education and Strategic Projects |
| University of the Witwatersrand | Oceanic Humanities for the Global South | 12/07/17 | $858,000 | Johannesburg, South Africa | International Higher Education and Strategic Projects |
| University of the Western Cape | Mellon Mays Undergraduate Fellowship | 10/18/17 | $100,000 | Bellville, South Africa | Higher Learning |
| University of the Western Cape | Artists in Residence Fellowship Program | 09/06/18 | $68,000 | Bellville, South Africa | International Higher Education and Strategic Projects |
| University of Cape Town | Ibuyambo Artists Residencies | 09/06/18 | $63,000 | Cape Town, South Africa | International Higher Education and Strategic Projects |
| Western Cape Tertiary Institutions Trust | Bandwidth Initiative | 01/11/99 | $5,000 | Cape Town, South Africa | International Higher Education and Strategic Projects |
| South African Bibliographic and Information Network | JSTOR - South Africa | 06/16/00 | $340,000 | Centurion, South Africa | International Higher Education and Strategic Projects |
| University of Natal | Demography - HIV/AIDS Node | 06/15/01 | $300,000 | Durban, South Africa | Past Programs |
