| Vanderbilt University | Medical Schools Program | 06/16/82 | $225,000 | Nashville, TN, United States | Past Programs |
| Yale University | Regional Theatre Program | 06/15/83 | $100,000 | New Haven, CT, United States | Arts and Culture |
| Yale University | Research Library Preservation Internships | 06/15/83 | $80,000 | New Haven, CT, United States | Higher Learning |
| University of the Witwatersrand | South African Universities | 06/14/88 | $900,000 | Johannesburg, South Africa | Other |
| Yeshiva University | Medical Schools Program | 06/14/88 | $225,000 | New York, NY, United States | Past Programs |
| Yale University | Jonathan Edwards Project | 06/07/93 | $40,000 | New Haven, CT, United States | Higher Learning |
| Yale University | Digitally Enabled Scholarship with Medieval Manuscripts | 09/13/12 | $650,000 | New Haven, CT, United States | Public Knowledge |
| Vanderbilt University | The Wisdom of the Elders | 08/03/15 | $77,300 | Nashville, TN, United States | Higher Learning |
| University of the Witwatersrand | Mellon Mays Undergraduate Fellowship | 09/15/16 | $97,000 | Johannesburg, South Africa | Higher Learning |
| University of the Witwatersrand | History Workshop | 09/15/16 | $858,000 | Johannesburg, South Africa | International Higher Education and Strategic Projects |
| University of the Witwatersrand | Wits School of Arts | 09/15/16 | $690,000 | Johannesburg, South Africa | International Higher Education and Strategic Projects |
| Yale University | James Boswell Papers | 10/04/78 | $60,000 | New Haven, CT, United States | Higher Learning |
| Vanderbilt University | 1980s Fund | 12/17/80 | $750,000 | Nashville, TN, United States | Higher Learning |
| Vanderbilt University | Educational Excellence Network | 12/15/82 | $35,000 | Nashville, TN, United States | Higher Learning |
| University of Vermont | Reproductive Biology [Auletta] | 12/17/85 | $297,000 | Burlington, VT, United States | Past Programs |
| Yale University | Mellon Mays Undergraduate Fellowship Program - Evaluation and Program | 12/10/90 | $6,000 | New Haven, CT, United States | Higher Learning |
| Wesleyan University | Mellon Mays Undergraduate Fellowship Program | 12/14/92 | $200,000 | Middletown, CT, United States | Higher Learning |
| Yale University | Ecosystems Research | 12/13/93 | $138,000 | New Haven, CT, United States | Past Programs |
| University of Washington | Ecosystems Research - Kruger National Park | 12/05/97 | $170,000 | Seattle, WA, United States | Past Programs |
| University of Virginia | Digital Scholarship | 12/17/99 | $1,000,000 | Charlottesville, VA, United States | Public Knowledge |
| University of Virginia | New Directions Fellowships [Wellmon] | 03/10/16 | $177,000 | Charlottesville, VA, United States | Higher Learning |
| Yale University | Artist Reference Collections Survey | 12/19/16 | $55,000 | New Haven, CT, United States | Arts and Culture |
| University of Virginia | Landscape Studies Initiative | 02/21/17 | $150,000 | Charlottesville, VA, United States | Higher Learning |
| University of Utah | Campus Library and Museum Collaboration | 12/07/17 | $500,000 | Salt Lake City, UT, United States | Arts and Culture |
| Yale University | Software Preservation Infrastructure | 12/07/17 | $1,000,000 | New Haven, CT, United States | Public Knowledge |
