| Southern Education Foundation, Inc. | Black College Libraries | 12/14/89 | $3,500,000 | Atlanta, GA, United States | Higher Learning |
| University of Southern California | Irei Names | 03/11/22 | $3,500,000 | Los Angeles, CA, United States | Other |
| American Council of Learned Societies | Dissertation Completion Fellowships | 03/05/20 | $3,500,000 | New York, NY, United States | Higher Learning |
| Rutgers, The State University of New Jersey | Humanities Fellowship Initiatives - Phase II | 06/03/11 | $3,500,000 | New Brunswick, NJ, United States | Higher Learning |
| The Studio Museum in Harlem | Critical Collections | 06/08/22 | $3,500,000 | New York, NY, United States | Arts and Culture |
| Associated Colleges of the South, Inc. | Environmental Studies | 09/18/08 | $3,500,000 | Atlanta, GA, United States | Higher Learning |
| Institute for Citizens and Scholars | Mellon Fellowships | 03/19/87 | $3,500,000 | Princeton, NJ, United States | Higher Learning |
| Anthology of Recorded Music, Inc. | General Operations | 03/20/06 | $3,500,000 | Brooklyn, NY, United States | Public Knowledge |
| Ekvnv Yefolecvlke | Vlahoke | 12/10/21 | $3,500,000 | Weogufka, AL, United States | Humanities in Place |
| Rockefeller University | Life Sciences Education | 03/30/90 | $3,500,000 | New York, NY, United States | Higher Learning |
| University of Virginia | The Global South | 06/04/15 | $3,470,000 | Charlottesville, VA, United States | Higher Learning |
| Social Science Research Council | Dissertation Proposal Development Fellowships | 06/13/08 | $3,465,000 | Brooklyn, NY, United States | Higher Learning |
| Foundation of the American Institute for Conservation of Historic and Artistic Works, Inc. | Photograph Conservation - State Hermitage Museum | 03/19/10 | $3,460,000 | Washington, DC, United States | Arts and Culture |
| American Council of Learned Societies | Ryskamp Research Fellowships | 06/18/10 | $3,451,000 | New York, NY, United States | Higher Learning |
| United Negro College Fund, Inc. | UNCF/Mellon Mays Undergraduate Fellowship Program | 03/14/13 | $3,406,350 | Washington, DC, United States | Higher Learning |
| Institute for Citizens and Scholars | Mellon Fellowships | 12/14/83 | $3,400,000 | Princeton, NJ, United States | Higher Learning |
| Carnegie Mellon University | Research Center on the Materials of the Artist and Conservator | 03/21/03 | $3,385,000 | Pittsburgh, PA, United States | Arts and Culture |
| American Council of Learned Societies | Ryskamp Research Fellowships | 06/15/07 | $3,380,000 | New York, NY, United States | Higher Learning |
| Princeton University | Society of Fellows in the Arts | 05/31/12 | $3,300,000 | Princeton, NJ, United States | Higher Learning |
| Institute for Citizens and Scholars | Mellon Fellowships | 12/16/81 | $3,300,000 | Princeton, NJ, United States | Higher Learning |
| New England Foundation for the Arts, Inc. | National Dance Project | 03/12/15 | $3,300,000 | Boston, MA, United States | Arts and Culture |
| Population Council | General support | 06/14/88 | $3,250,000 | New York, NY, United States | Past Programs |
| Museum Associates | Mellon Undergraduate Curatorial Fellowship | 09/11/17 | $3,250,000 | Los Angeles, CA, United States | Arts and Culture |
| American Council of Learned Societies | Dissertation Completion Fellowships | 06/06/19 | $3,250,000 | New York, NY, United States | Higher Learning |
| American Council of Learned Societies | Dissertation Fellowships/Fellowships for Recent Recipients of the PhD | 03/20/06 | $3,200,000 | New York, NY, United States | Higher Learning |
