| Illinois College | Faculty Career Enhancement | 07/02/07 | $50,000 | Jacksonville, IL, United States | Higher Learning |
| St. Olaf College | New President - Strategic Planning | 10/03/07 | $50,000 | Northfield, MN, United States | Higher Learning |
| University of Illinois at Urbana-Champaign | Mellon Award for Technology Collaboration [Firefox] | 10/03/07 | $50,000 | Champaign, IL, United States | Higher Learning |
| American Council on Education | Demographic Study | 06/16/87 | $50,000 | Washington, DC, United States | Higher Learning |
| Columbia University | Soviet System Study | 06/16/87 | $50,000 | New York, NY, United States | Higher Learning |
| University of Chicago | Middle Eastern Studies - Arabic Summer Instruction | 06/11/90 | $50,000 | Chicago, IL, United States | Higher Learning |
| New York State Archives Partnership Trust | Colonial/State Records Preservation | 05/18/94 | $50,000 | Albany, NY, United States | Higher Learning |
| Tulane University | Paperless Application Project | 06/17/96 | $50,000 | New Orleans, LA, United States | Higher Learning |
| American Council of Learned Societies | Presidential Transition Activities | 04/10/97 | $50,000 | New York, NY, United States | Higher Learning |
| Organization of American Historians | Electronic Historical Editing | 04/16/97 | $50,000 | Bloomington, IN, United States | Higher Learning |
| Gustavus Adolphus College | Emergency Needs | 05/08/98 | $50,000 | St. Peter, MN, United States | Higher Learning |
| Cornell College | Reimagining the Liberal Arts Experience Through Innovation and Integration | 04/24/17 | $50,000 | Mount Vernon, IA, United States | Higher Learning |
| National Academy of Sciences | Research Universities and the Future of America: A National Convocation | 05/22/17 | $50,000 | Washington, DC, United States | Higher Learning |
| Newberry Library | Historical Map/Atlas Collection | 06/22/71 | $50,000 | Chicago, IL, United States | Higher Learning |
| Claremont McKenna College | Hewlett-Mellon Program | 10/02/84 | $50,000 | Claremont, CA, United States | Higher Learning |
| Bates College | New President | 06/11/04 | $50,000 | Lewiston, ME, United States | Higher Learning |
| Bowdoin College | Mellon Mays Undergraduate Fellowship Program - Video | 05/09/05 | $50,000 | Brunswick, ME, United States | Higher Learning |
| American University of Paris, Inc. | American International Consortium of Academic Libraries | 04/10/06 | $50,000 | Paris, France | Higher Learning |
| Woodrow Wilson National Fellowship Foundation | Secondary School Teacher Retention Project | 04/17/06 | $50,000 | Princeton, NJ, United States | Higher Learning |
| Union College | New President | 06/15/07 | $50,000 | Schenectady, NY, United States | Higher Learning |
| University of Wisconsin at Madison | New Directions Post-Fellowship Award [Huang] | 05/17/10 | $50,000 | Madison, WI, United States | Higher Learning |
| Randolph-Macon College | New President - Strategic Planning | 06/23/08 | $50,000 | Ashland, VA, United States | Higher Learning |
| Columbia University | New Directions Post-Fellowship Award [Smith] | 07/21/08 | $50,000 | New York, NY, United States | Higher Learning |
| Indiana University | Emeritus Fellowships [Johnston] | 09/18/08 | $50,000 | Bloomington, IN, United States | Higher Learning |
| George Mason University | Mellon Award for Technology Collaboration [Project Omeka] | 09/18/08 | $50,000 | Fairfax, VA, United States | Higher Learning |
