| American Council of Learned Societies | Fellowship Endowment | 03/30/90 | $2,500,000 | New York, NY, United States | Higher Learning |
| Institute of International Education, Inc. | Responding to the Urgent Need for Supporting Academics in Peril | 12/07/17 | $2,500,000 | New York, NY, United States | Higher Learning |
| University of Wisconsin at Madison | Institutional Excellence Initiatives - Faculty Lines | 03/13/09 | $2,500,000 | Madison, WI, United States | Higher Learning |
| Harvard University | Villa I Tatti | 06/18/74 | $2,500,000 | Cambridge, MA, United States | Higher Learning |
| University of California at Berkeley | Institutional Excellence Initiatives - Research Support for Associate Professors | 06/15/07 | $2,500,000 | Berkeley, CA, United States | Higher Learning |
| Duke University | Institutional Excellence Initiatives - Visual Studies | 09/15/06 | $2,500,000 | Durham, NC, United States | Higher Learning |
| Cornell University | Institutional Excellence Initiatives - Professorships in the Humanities | 10/03/07 | $2,500,000 | Ithaca, NY, United States | Higher Learning |
| The University of British Columbia | Kuali Student Services System | 10/03/07 | $2,500,000 | Vancouver, British Columbia, Canada | Higher Learning |
| New York University | Institutional Excellence Initiatives - Graduate Student Support in the Humanities | 12/09/10 | $2,500,000 | New York, NY, United States | Higher Learning |
| Columbia University | Graduate Education Endowment | 09/17/99 | $2,500,000 | New York, NY, United States | Higher Learning |
| Vera Institute of Justice, Inc. | Second Chance Pell Program and Expanding Access for Incarcerated Students | 12/11/20 | $2,500,000 | Brooklyn, NY, United States | Higher Learning |
| United Negro College Fund, Inc. | UNCF/Mellon Faculty Career Enhancement Programs | 12/11/20 | $2,500,000 | Washington, DC, United States | Higher Learning |
| University of Chicago | Graduate Fellowship Support | 03/16/01 | $2,500,000 | Chicago, IL, United States | Higher Learning |
| Southwestern University | National Institute for Technology in Liberal Education - Western Center | 03/20/06 | $2,500,000 | Georgetown, TX, United States | Higher Learning |
| University of Toronto | FLUID Project | 03/16/07 | $2,500,000 | Toronto, Ontario, Canada | Higher Learning |
| Emeriti Consortium for Retirement Health Solutions | Administrative Funding | 09/17/05 | $2,500,000 | New Windsor, NY, United States | Higher Learning |
| University of California at Los Angeles | Institutional Excellence Initiatives - Departmental Renewal | 09/15/06 | $2,500,000 | Los Angeles, CA, United States | Higher Learning |
| University of Wisconsin at Madison | Integrated Humanities Education | 09/10/15 | $2,500,000 | Madison, WI, United States | Higher Learning |
| Woodrow Wilson National Fellowship Foundation | Mellon Fellowships | 12/12/84 | $2,500,000 | Princeton, NJ, United States | Higher Learning |
| Five Colleges, Incorporated | Native/Indigenous Studies Development | 12/09/19 | $2,500,000 | Amherst, MA, United States | Higher Learning |
| Institute of International Education, Inc. | Responding to the Urgent Need for Supporting Academics in Peril - Phase II | 03/05/20 | $2,500,000 | New York, NY, United States | Higher Learning |
| University of Pennsylvania | Institutional Excellence Initiatives - Democracy, Citizenship, and Constitutionalism | 09/15/06 | $2,500,000 | Philadelphia, PA, United States | Higher Learning |
| Wellesley College | Faculty Career Enhancement | 12/15/00 | $2,500,000 | Wellesley, MA, United States | Higher Learning |
| American Museum of the Moving Image | CollectionSpace | 12/11/07 | $2,500,000 | Astoria, NY, United States | Higher Learning |
| Social Science Research Council | Mellon Mays Undergraduate Fellowship Program - Graduate Initiatives Program | 12/17/08 | $2,500,000 | Brooklyn, NY, United States | Higher Learning |
