| From the Heart Productions, Inc. | The Clifton House Launch and Programming | 09/18/20 | $750,000 | Oxnard, CA, United States | Other |
| John F. Kennedy Center for the Performing Arts | Social Impact Fund | 09/18/20 | $3,000,000 | Washington, DC, United States | Arts and Culture |
| American Council of Learned Societies | Mellon Leading Edge Fellowships | 09/18/20 | $3,600,000 | New York, NY, United States | Higher Learning |
| Scholars at Risk, Inc. | Free to Think: Documenting Attacks on Universities, Scholars & Academic Freedom | 09/18/20 | $400,000 | New York, NY, United States | Higher Learning |
| Gallaudet University | Visual-Centric Teaching and Learning | 09/18/20 | $800,000 | Washington, DC, United States | Higher Learning |
| The Graduate Center of the City University of New York | Sawyer Seminar - Race and the Middle East/North Africa | 09/18/20 | $225,000 | New York, NY, United States | Higher Learning |
| Rice University | Sawyer Seminar - Diasporic Cultures of Slavery: Engaging Disciplines, Engaging Communities | 09/18/20 | $225,000 | Houston, TX, United States | Higher Learning |
| University of California at Santa Barbara | Sawyer Seminar - Race, Precarity, and Privilege: Migration in a Global Context | 09/18/20 | $225,000 | Santa Barbara, CA, United States | Higher Learning |
| Rutgers, The State University of New Jersey at Newark | Sawyer Seminar - Natives and Nativists, Migrants and Immigrants in an American City | 09/18/20 | $225,000 | Newark, NJ, United States | Higher Learning |
| Tulane University | Sawyer Seminar - Sites of Memory: New Orleans and Place-based Histories in the Americas | 09/18/20 | $225,000 | New Orleans, LA, United States | Higher Learning |
| Oregon Shakespeare Festival Association, Inc. | OSF Rebuilds | 09/18/20 | $1,000,000 | Ashland, OR, United States | Arts and Culture |
| Washington State University | Mukurtu Shared: Phase II | 09/18/20 | $700,000 | Pullman, WA, United States | Public Knowledge |
| The Rebus Foundation | Rebus Ink | 09/18/20 | $762,000 | Montreal, QC, Canada | Public Knowledge |
| Portland Institute for Contemporary Art | Creative Exchange Lab | 09/18/20 | $580,000 | Portland, OR, United States | Arts and Culture |
| The Connecticut Players Foundation, Inc. | Collaborative Disruption | 09/18/20 | $350,000 | New Haven, CT, United States | Arts and Culture |
| Center Stage Associates, Inc. | Collaborative Disruption | 09/18/20 | $350,000 | Baltimore, MD, United States | Arts and Culture |
| Houston Grand Opera Association, Inc. | Development and Production of New American Works | 09/18/20 | $500,000 | Houston, TX, United States | Arts and Culture |
| Teachers College–Columbia University | Guided Pathways | 09/18/20 | $500,000 | New York, NY, United States | Higher Learning |
| ARRAY Alliance, Inc. | The Law Enforcement Arts Accountability Project | 09/18/20 | $500,000 | Encino, CA, United States | Other |
| Tougaloo College | Institute for Social Justice | 09/18/20 | $500,000 | Tougaloo, MS, United States | Higher Learning |
| Xavier University of Louisiana | Celebrating African Diasporic Cultures | 09/18/20 | $500,000 | New Orleans, LA, United States | Higher Learning |
| The Library Company of Philadelphia | Mellon Scholars Program | 09/18/20 | $500,000 | Philadelphia, PA, United States | Higher Learning |
| University of Houston | Mellon Research Scholars Program Part II | 09/18/20 | $500,000 | Houston, TX, United States | Higher Learning |
| International Institute for Asian Studies, Leiden University | Humanities Across Borders 2.0: Asia and Africa in the World | 09/18/20 | $900,000 | Leiden, Netherlands | Higher Learning |
| Brown University | Sawyer Seminar - Rethinking the Dynamic Interplay of Migration, Race, and Ethnicity in the Caribbean and Latin America | 09/18/20 | $225,000 | Providence, RI, United States | Higher Learning |
