| University of Puerto Rico at Río Piedras | Afro-Diasporic and Racial Studies Major and Minor | 12/11/20 | $700,000 | San Juan, PR, United States | Higher Learning |
| Michigan State University | Puerto Rico Disaster Archive | 06/04/20 | $325,000 | East Lansing, MI, United States | Other |
| Northwestern University | Puerto Rico Arts Initiative | 06/04/20 | $750,000 | Evanston, IL, United States | Arts and Culture |
| Instituto de Cultura Puertorriqueña | General Archives Digital Collections | 06/04/20 | $2,000,000 | San Juan, PR, United States | Other |
| Fundación Luis Muñoz Marín, Inc. | Puerto Rico Architectural Heritage Archive | 06/04/20 | $1,000,000 | San Juan, PR, United States | Other |
| Flamboyan Foundation, Inc. | Puerto Rico Arts Emergency Relief Fund | 04/27/20 | $500,000 | Washington, DC, United States | Other |
| Henry Street Settlement | Partnership Development in Puerto Rico | 12/17/19 | $150,000 | New York, NY, United States | Arts and Culture |
| Visual Arts Research & Resource Center Relating to the Caribbean, Inc. | Corredor Afro | 12/09/19 | $300,000 | New York, NY, United States | Other |
| Productora Angeles Del Fin, Inc. | Nido Cultural (Shared Services for Puerto Rican Artists) | 12/09/19 | $500,000 | San Lorenzo, PR, United States | Other |
| Artspace Projects, Inc. | Puerto Rico Feasibility Study | 12/09/19 | $150,000 | Minneapolis, MN, United States | Other |
| Grantmakers in the Arts | Grantmakers in the Arts Annual Conferences | 08/19/19 | $150,000 | Bronx, NY, United States | Arts and Culture |
| Museo de Arte Contemporáneo de Puerto Rico, Inc. | Capacity Building | 06/06/19 | $1,000,000 | San Juan, PR, United States | Arts and Culture |
| Beta-Local, Inc. | Support for Staff Infrastructure and Regranting | 03/06/19 | $230,000 | San Juan, PR, United States | Other |
| Museo De Arte De Puerto Rico, Inc. | Hurricane recovery | 05/31/18 | $250,000 | San Juan, United States | Arts and Culture |
| Northwestern University | Puerto Rico artist development initiative | 05/31/18 | $500,000 | Evanston, United States | Arts and Culture |
| Luis A. Ferré Foundation, Inc. | Cash reserve | 05/31/18 | $500,000 | Ponce, PR, United States | Arts and Culture |
| Brown University | Emergency Support for UPR after Hurricane Maria | 12/14/17 | $150,000 | Providence, RI, United States | Higher Learning |
| Luis A. Ferré Foundation, Inc. | Conservation & Curatorial Support - Part II | 06/13/16 | $500,000 | Ponce, PR, United States | Arts and Culture |
| University of Puerto Rico at Río Piedras | Mellon May Undergraduate Fellowship Program | 03/12/15 | $500,000 | San Juan, PR, United States | Higher Learning |
| University of Puerto Rico at Mayagüez | Plants Initiative | 12/06/12 | $22,000 | Mayagüez, PR, United States | Past Programs |
| Luis A. Ferré Foundation, Inc. | Conservation and Curatorial Support | 12/01/11 | $500,000 | Ponce, PR, United States | Arts and Culture |
| New York Botanical Garden | Digitization - Collections - Puerto Rico | 12/12/05 | $100,000 | Bronx, NY, United States | Past Programs |
| University of Puerto Rico | Ecosystems Research - Zimmerman | 03/20/00 | $239,000 | San Juan, PR, United States | Past Programs |
| New York University | Puerto Rican Economy | 09/30/91 | $300,000 | New York, NY, United States | Other |
| CEREP, Inc. | Plebiscite Education - Puerto Rico | 12/10/90 | $75,000 | Rio Piedras, PR, United States | Other |
